唇瘡 痱滋 | Aphthous Ulcer
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什麼是阿弗他潰瘍(唇/口瘡)？
阿弗他口腔潰瘍（aphthae）是一種常見的潰瘍，形成於粘膜，通常長在口腔內。唇瘡的其他名稱包括阿弗他口炎和潰瘍。
唇瘡通常是圓形的形狀長於嘴內，如嘴唇內部，臉頰內或舌底。他們是良性的，非傳染性的，可以發生單一的潰瘍或集羣。在大多數情况下，唇瘡是會復發性的，這種情況被稱為復發性阿弗他口炎（RAS），每次發作通常持續7到10天。
這種情況的原因尚不清楚，也沒有治癒的方法，但可以選擇治療潰瘍可能引起的疼痛。
唇瘡是最常見的口腔潰瘍類型，但他們不是唯一的一種。
主要有三種類型：
小口瘡
這些是最常見的品種。它們體積小，直徑通常小於5毫米，可形成單一潰瘍或叢生潰瘍。它們通常不會引起太多疼痛。
大阿弗他潰瘍
這些是不太常見的，通常是5毫米或更大，形成單一或成對。他們可能會很痛苦，尤其是在吃或喝的時候，而且會持續兩周到幾個月。
皰疹樣潰瘍
當多個病灶融合在一起形成不規則形狀的大潰瘍時，就會發生這種情況。皰疹樣潰瘍之所以被稱為皰疹，是因為它們在外觀上與皰疹相似，然而，皰疹樣潰瘍並不是由單純皰疹病毒引起的。
高濃参碱蜂膠液 (食用加外塗)
在這項隨機、雙盲、安慰劑對照研究中，患者被分配每天服用500毫克蜂膠或安慰劑膠囊。受試者報告基線潰瘍頻率，並每兩周聯系一次以記錄復發情况。對數據進行分析，以確定受試者的爆發頻率是否下降了50%。資料表明蜂膠組的暴發在統計學上顯著减少（Fisher精確檢驗，單側，p=0.04）。蜂膠組的患者也自我報告其生活質量顯著改善（p=0.03）。這項研究表明蜂膠能有效地减少RAS患者的復發次數，提高患者的生活質量。(5)
口腔潰瘍的相關研究:
* 暴發在統計學上顯著减少(1)
* 生活質量顯著改善(1)
* 减少口腔潰瘍患者的復發次數 (1)
* 减少生物膜生成，加速傷口癒合(2)
* 高水准的抗HSV-2的抗病毒活性 (3)
* 感染性顯著降低>99%(3)
* 表現出較高的抗皰疹病毒活性(3)
* 可能適合復發性皰疹感染的局部治療(3)
* 治療細菌感染(4)
What are aphthous ulcers?
Aphthous mouth ulcers (aphthae) are a common variety of ulcer that form on the mucous membranes, typically in the oral cavity (mouth). Other names for aphthous ulcers include aphthous stomatitis and canker sores.
Aphthous ulcers are generally round in shape and form in the soft areas of the mouth such as the inside of the lips, the cheeks or the underside of the tongue. They are benign, non-contagious and can occur as single ulcers or in clusters. In most instances, aphthous ulcers are recurrent – a condition known as recurrent aphthous stomatitis (RAS) – with each episode normally lasting for between 7 and 10 days.
The cause of the condition is unclear, and there is no cure, but treatment options are available to treat the pain the ulcers can cause.
Aphthous ulcers are the most common type of mouth ulcer, but they are not the only kind of mouth ulcers.
There are three main types:
Minor aphthous ulcers
These are the most common variety. They are small in size – usually less than 5 mm in diameter – and can form as a single ulcer or in a cluster. They typically do not cause much pain.
Major aphthous ulcers
These are less common, are generally 5 mm or larger and form singularly or in a pair. They can be painful, especially when eating or drinking, and last anywhere between two weeks and a number of months.
Herpetiform ulcers
These can occur when multiple pinpoint lesions fuse together and form large, irregularly shaped ulcers. Herpetiform ulcers are so called because of their similarity in appearance to herpes, however, herpetiform ulceration is not caused by the herpes simplex virus.
High Concentration Matrine Propolis (Oral and Topical)
The purpose of this pilot study was to evaluate the potential of a product to reduce the number of outbreaks of RAS ulcers. Propolis is a bee product used in some cultures as treatment for mouth ulcers. In this randomized, double-blind, placebo-controlled study, patients were assigned to take 500 mg of propolis or a placebo capsule daily. Subjects reported a baseline ulcer frequency and were contacted biweekly to record recurrences. Data were analyzed to determine if subjects had a decrease of 50% in outbreak frequency. The data indicated a statistically significant reduction of outbreaks in the propolis group (Fisher's exact test, one sided, p = 0.04). Patients in the propolis group also self-reported a significant improvement in their quality of life (p = 0.03). This study has shown propolis to be effective in decreasing the number of recurrences and improve the quality of life in patients who suffer from RAS.
Research on oral ulcer:
*Significant reduction in outbreaks (1)
*Significant improvement in quality of life (1)
*Reducing the recurrence of oral ulcer (1)
*Reduce biofilm formation and accelerate wound healing (2)
*High level antiviral activity against HSV-2 (3)
*The infectivity was significantly reduced by more than 99% (3)
*It showed high anti herpesvirus activity (3)
*Local treatment for recurrent herpes infection (3)
*Treatment of bacterial infection (4)
參考研究 Refs:
- Nachum Samet 1 , Caroline Laurent, Srinivas M Susarla, Naama Samet-Rubinsteen The effect of bee propolis on recurrent aphthous stomatitis: a pilot study Clin Oral Investig . 2007 Jun;11(2):143-7. doi: 10.1007/s00784-006-0090-z. Epub 2007 Feb 7. PMID: 17285269 . DOI: 10.1007/s00784-006-0090-z
- AhmadOryana, EsmatAlemzadehb, AliMoshiric. Potential role of propolis in wound healing: Biological properties and therapeutic activities. Biomedicine & Pharmacotherapy. Volume 98, February 2018, Pages 469-483. https://doi.org/10.1016/j.biopha.2017.12.069
- Silke Nolkemper,Jürgen Reichling,Karl Heinz Sensch,Paul Schnitzler September 2009. Mechanism of herpes simplex virus type 2 suppression by propolis extracts. 17(2):132-8. Phytomedicine: International Journal of Phytotherapy and PhytopharmacologyI: 10.1016/j.phymed.2009.07.006
- Venkataramanujam Srinivasan 1 , Mahaneem Mohamed, Hisanori Kato. Melatonin in bacterial and viral infections with focus on sepsis: a review. Recent Pat Endocr Metab Immune Drug Discov. 2012 Jan;6(1):30-9.doi: 10.2174/187221412799015317. PMID: 22264213
- Nachum Samet 1 , Caroline Laurent, Srinivas M Susarla, Naama Samet-Rubinsteen The effect of bee propolis on recurrent aphthous stomatitis: a pilot study Clin Oral Investig . 2007 Jun;11(2):143-7. doi: 10.1007/s00784-006-0090-z. Epub 2007 Feb 7. PMID: 17285269 . DOI: 10.1007/s00784-006-0090-z
If you have this disease, please follow your doctor's complete medical plan. You must consult the attending doctor before using the multidisciplinary rehabilitation plan. If your attending doctor does not recommend you to join the supplement conditioning combination, please do not use it. If you need to seek second consultation from other doctors, you can contact our online "Doctors Without Borders", or another professional doctor in your own city.
