嚴重骨關節炎 | Severe Arthritis
骨關節炎
骨關節炎(OA)的特徵包括關節退行性變、軟骨遺失和軟骨下骨改變。它是最常見的關節炎,發病率最高。它主要影響老年人,但35%的發病率早在30歲就開始了(通常診斷為髕骨軟骨軟化症)。發病率隨著年齡的增長而急劇增加。超過4000萬美國人患有骨性關節炎,其中80%的人年齡在50歲以上。OA負責25%的初級保健醫生的辦公室就診。男性和女性同樣受到影響,但症狀出現得更早,女性似乎更嚴重。
修復關節炎的多靶點方向:
- 治療運動員關節疼痛的改善(2)
- 降低高危人群關節惡化(2)
- 治療骨關節炎的潜在營養補充劑(3)
- 軟組織腫脹減輕(4)
- 治療後4周疼痛指數持續下降80%(5)
- 口服酶製劑可能是治療疼痛性膝關節炎的有效和安全的選擇(6)
Osteoarthritis (OA)
Osteoarthritis (OA) characteristics include joint degeneration, loss of cartilage, and alterations of subchondral bone. It is the most common form of arthritis, with the highest morbidity rate of any illness. It primarily affects the elderly, but 35% of its incidence in the knee starts as early as age 30 years (often diagnosed as chondromalacia patellae). The incidence dramatically increases with age. More than 40 million Americans have OA, including 80% of persons older than 50 years. OA is responsible for 25% of all office visits to primary care physicians. Men and women are equally affected, but symptoms occur earlier and appear to be more severe in women.
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• Diseases thought to be OA of specific joints: hands (Heberden’s and Bouchard’s nodes), hips (malum coxae senilis), temporomandibular joint (Costen’s syndrome), knees (chondromalacia patellae), and spine (ankylosing hyperostosis, interstitial skeletal hyperostosis).
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- • Weight-bearing joints and peripheral and axial articulations are principally affected. Hyaline cartilage destruction is followed by hardening and formation of large bone spurs (calcified osteophytes) in joint margins, causing pain, deformity, and limited joint motion. Inflammation usually is minimal.
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• Two categories of OA: (1) primary OA arises from wear and tear after the fifth and sixth decades, with no predisposing abnormalities. The cumulative effects of decades of use stress collagen matrix. Damage releases enzymes that destroy collagen components. With aging, the ability to synthesize restorative collagen decreases. (2) Secondary OA entails predisposing factors for degeneration. Factors include congenital abnormalities in joint structure or function (e.g., hypermobility and abnormally shaped joint surfaces), trauma (obesity, fractures along joint surfaces, surgery), crystal deposition, presence of abnormal cartilage, previous inflammatory disease of joint (rheumatoid arthritis [RA], gout, septic arthritis).
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- • OA severity, as determined by radiography, does not correlate with degree of pain. Normal-looking joints, with little joint-space narrowing, can be excruciatingly painful. Conversely, joints with tremendous deformity may have little pain. In fact, 40% of patients with the worst x-ray classification for OA are pain free. The cause of pain is ill defined, but there are numerous potential causes. Depression and anxiety increase the experience of OA pain.(1)
- Osteoarthritis. Joseph E. Pizzorno ND, ... Herb Joiner-Bey ND, in The Clinician's Handbook of Natural Medicine (Third Edition), 2016
- Kristine L Clark 1 , Wayne Sebastianelli, Klaus R Flechsenhar, Douglas F Aukermann, Felix Meza, Roberta L Millard, John R Deitch, Paul S Sherbondy, Ann Albert. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Randomized Controlled Trial. Curr Med Res Opin. 2008 May;24(5):1485-96.doi: 10.1185/030079908x291967. Epub 2008 Apr 15. PMID: 18416885
- Suresh Kumar1 , Fumihito Sugihara, Keiji Suzuki, Naoki Inoue, Sriraam Venkateswarathirukumara. A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis. PMID: 24852756 DOI: 10.1002/jsfa.6752
- BROMELAINS THERAPY IN RHEUMATOID ARTHRITIS. COHEN A, GOLDMAN J Pa Med J. 1964 Jun; 67():27-30.
- Klein G, Kullich W. Short-term treatment of painful osteoarthritis of the knee with oral enzymes: a randomised, double-blind study versus Diclofenac. Clin Drug Invest. 2000;19:15–23.
- Klein G, Kullich W. Short-Term Treatment of Painful Osteoarthritis of the Knee with Oral Enzymes: A Randomised, Double-Blind Study versus Diclofenac. January 2000Clinical Drug Investigation 19(1):15-23. DOI: 10.2165/00044011-200019010-00003