尿酸結晶 - 多學科復康 | Uric Acid Crystal (MRP)
尿酸結晶
學術界和臨床實踐界對痛風的興趣越來越大。有幾個原因可以解釋這一點。在過去的幾十年裏，已開發國家高尿酸血症和痛風的患病率都在上升，囙此痛風的負擔也在新增。高尿酸血症和痛風與心血管結局的關係以及高尿酸血症干預進一步獲益的機會最近在文獻中被強調。成像科技已被證明是有用的檢測尿酸鹽沉積，甚至之前的第一個臨床症狀，使沉積程度的評估，並提供客觀的量測晶體損耗尿酸降低治療。靶向治療越來越多地被用作治療各種疾病的方法。囙此，針對疾病負擔的不同階段和治療的不同階段，建議了不同的靶點。最終的戰略目標是完全溶解組織中的尿酸鹽晶體，從而避免肌肉骨骼結構的進一步症狀和結構損傷。總之，有證據表明，早期治療痛風和相關的共病是可取的，新的成像科技可能有助於評估特定患者的沉積負擔和對降低尿酸治療的反應，最後，痛風患者醫療保健的最終戰略目標是完全分解尿酸鹽晶體沉積。
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Uric Acid Crystal
There has been increased interest in gout in both academic and clinical practice settings. Several reasons may explain this. The prevalence of both hyperuricemia and gout has risen in the last decades in developed countries and therefore the burden of gout has increased. The association of hyperuricemia and gout with cardiovascular outcomes and the opportunity of further benefits of intervention on hyperuricemia have been recently highlighted in the literature. Imaging techniques have proven to be useful for detection of urate deposition, even prior to the first clinical symptoms, enabling the evaluation of the extent of deposition and providing objective measurement of crystal depletion during urate-lowering treatment. Treating to target is increasingly used as the approach to treatment of diverse diseases. Therefore, different targets have been recommended for different stages of the burden of disease and for different stages of treatment. The final strategic target, to which any effort should be taken into consideration, is to completely dissolve urate crystals in tissues and therefore avoid further symptoms and structural damage of involved musculoskeletal structures. In summary, evidence suggest that an early approach to the treatment of gout and associated comorbidities is advisable, that new imaging techniques may help to evaluate both the burden of deposition and response to urate-lowering treatment in selected patients, and finally that the final strategic objective of healthcare for patients with gout is to completely resolve urate crystal deposits.
Ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43110...
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