Ankylosing spondylitis (AS) is a chronic immune-mediated inflammatory arthritis included in the so-called group of spondyloarthritis (SpA). It typically develops in males in their third decade of life and affects mainly the axial skeleton and the sacroiliac joints. Although the oldest descriptions date from the time of Galen, it was not until the 19th century that the disease could be accurately diagnosed on the basis of reports by Vladimir Bekhterev, Adolph Strümpell, and Pierre Marie. The HLA-B27 allele is known to have a strong association with the disease 1; however, other genes play a part in its development. The discovery of several inflammatory pathways led to the era of the biologic therapies, which meant a revolution in the treatment and prognosis of AS.
If you have this disease, please follow your doctor's complete medical plan. You must consult the attending doctor before using the multidisciplinary rehabilitation plan. If your attending doctor does not recommend you to join the supplement conditioning combination, please do not use it. If you need to seek second opinion from other doctors, you can contact our online "Doctors Without Borders", or another professional doctor in your own city.