排重金屬 | Removal Of Heavy Metal

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排重金屬

排毒是從體內清除藥物、誘變劑和其他有害物質的能力。通過能够螯合幾種重金屬的微生物群，排毒作用發生在腸道、肝臟和腎臟。例如，血鉛、汞和鋅水准的新增與老年人的肌細胞减少症有關。此外，頭髮汞含量新增（而不是尿汞含量）與女性狼瘡性腹膜炎標記物（核抗原：ANA）標題升高相關。食物衍生化合物中的幾種代謝途徑與解毒有關。囙此，臨床方案能够防止重金屬積累是必要的，病人結合長期營養補充。抗氧化劑有助於螯合活性氧（ROS）通過去除重金屬，囙此，從植物中篩選新的抗氧化劑是重要的臨床觀點。(1)

生物綠藻、螯合成份於重金屬的作用:

  • 降低了某些重金屬水准（汞Hg++、銀Ag、錫Sn、鉛Pb和鈾U）(1)
  • 减少了汞在組織中的沉積(2)
  • 鉛中毒的螯合治療(3)
  • 螯合療法去除污染金屬减少人體內自由基的產生(4)
  • 螯合療法减少DNA氧化損傷和脂質過氧化(5)
  • 螯合療法被用於消除鎘中毒(6)
  • 顯著减少鋁中毒(7)
  • 長期螯合療法清除慢性鋁中毒(8)


Removal Of Heavy Metal

Detoxification is the ability to remove drugs, mutagens, and other harmful agents from the body. The detoxification takes place in the intestinal tract, the liver, and the kidneys by microbiota able to chelate several heavy metals [20,21]. For instance, increased blood lead, mercury, and zinc levels were associated with Sarcopenia in the elderly population [6]. In addition, increased hair mercury levels (but not urinary levels) were correlated with the elevated title for the Lupus Eritematose marker in women (nuclear antigen: ANA) [10]. Several metabolic pathways in food-derived compounds are involved in detoxification [21]. Thus, clinical protocols able to prevent heavy metal accumulation are necessary in patients in conjunction with long-term nutritional supplementation. Antioxidants contribute to chelating reactive oxygen species (ROS) by removing heavy metals; thus, the screening of new antioxidants from plants is important from a clinical view point.


The function of biological green algae and chelating components in heavy metals is as follows

  • Reduced levels of some heavy metals (Hg + +, Ag, Sn, Pb and U) (1)
  • Reduced mercury deposition in tissues (2)
  • Chelating therapy for lead poisoning (3)
  • Chelation therapy to remove contaminated metals and reduce the production of free radicals in human body (4)
  • Chelation therapy reduces DNA oxidative damage and lipid peroxidation (5)
  • Chelation therapy for elimination of cadmium poisoning (6)
  • Significant reduction of aluminum poisoning (7)
  • Long term chelation therapy for chronic aluminum poisoning (8)

Refs:
  1. José Joaquín Merino1,*, José María Parmigiani-Izquierdo1, Adolfo Toledano Gasca2 and María Eugenia Cabaña-Muñoz1. The Long-Term Algae Extract (Chlorella and Fucus sp) and Aminosulphurate Supplementation Modulate SOD-1 Activity and Decrease Heavy Metals (Hg++, Sn) Levels in Patients with Long-Term Dental Titanium Implants and Amalgam Fillings Restorations. Antioxidants 2019, 8(4), 101; https://doi.org/10.3390/antiox8040101
  2. Mahendra Yadav, Komal Rani, Meenakshi Kanwar Chauhan, Anuj Panwar & Nidhi Sandal. Published: 13 February 2020. Evaluation of mercury adsorption and removal efficacy of pulverized Chlorella (C. vulgaris). Journal of Applied Phycology volume 32, pages1253–1262(2020)
  3. Panariti E, Berxholi K. Lead toxicity in humans from contaminated flour in Albania. Vet Hum Toxicol. 1998 Apr; 40(2):91-2.
  4. Hininger I, Waters R, Osman M, Garrel C, Fernholz K, Roussel AM, Anderson RA. Acute prooxidant effects of vitamin C in EDTA chelation therapy and long-term antioxidant benefits of therapy. Free Radic Biol Med. 2005 Jun 15; 38(12):1565-70.
  5. Roussel AM, Hininger-Favier I, Waters RS, Osman M, Fernholz K, Anderson RA. EDTA chelation therapy, without added vitamin C, decreases oxidative DNA damage and lipid peroxidation. Altern Med Rev. 2009 Mar; 14(1):56-61.
  6. Gil HW, Kang EJ, Lee KH, Yang JO, Lee EY, Hong SY. Effect of glutathione on the cadmium chelation of EDTA in a patient with cadmium intoxication. Hum Exp Toxicol. 2011 Jan; 30(1):79-83.
  7. Fulgenzi A, Vietti D, Ferrero ME. Aluminium involvement in neurotoxicity. Biomed Res Int. 2014; 2014():758323.
  8. Fulgenzi A, De Giuseppe R, Bamonti F, Vietti D, Ferrero ME. Efficacy of chelation therapy to remove aluminium intoxication. J Inorg Biochem. 2015 Nov; 152():214-8.
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