灰甲 (甲癬) | Onychomycosis

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灰甲(甲癬)

灰甲-甲真菌病是最常見的指甲感染性疾病。主要由嗜人皮膚真菌引起，尤其是紅色毛癬菌和叉指芒癬菌。酵母菌，如白色念珠菌和副絲蟲病，黴菌，如麯黴屬，代表了甲真菌病的第二個原因。甲真菌病的臨床疑點應該是我的真菌學證實。甲真菌病是一種新的方法，可以幫助醫生，因為在甲真菌病，它顯示了一個典型的邊緣邊緣近。治療方法的選擇取決於指甲侵入的管道、真菌種類和受累指甲的數量。口服治療往往受到藥物相互作用的限制，而局部抗真菌漆的療效較差。口服和全身治療相結合往往是最佳選擇。(1)

  • 蜂膠液對灰甲(甲癬)的作用:
  • 抑制念珠菌(2,3)
  • 抗真菌的潜力(1)
  • 治療甲真菌病的選擇(1)
  • 念珠菌屬抑制劑(4)
  • 鐮刀菌屬具有活性(6)
  • 毛癬菌屬具良好抗真菌效能(5,7)
  • 對傷口癒合有益作用(5)
  • 穿透指甲而不產生細胞毒性(5)


Onychomycosis

Onychomycosis is a fungal nail infection, considered as a public health problem because it is contagious and it interferes with the quality of life. It has long and difficult treatment, with many side effects and high cost. Propolis extract (PE) is a potential alternative to conventional antifungal agents because it has low cost, accessibility, and low toxicity. Herein, we report the favorable response of PE in onychomycosis in three elderly patients.

The effect of propolis on onychomycosis was as follows

  • Inhibition of Candida (2,3)
  • Antifungal potential (1)
  • Choice of treatment for onychomycosis (1)
  • Candida inhibitors (4)
  • Fusarium is active (6)
  • Trichophyton has good antifungal activity (5,7)
  • Beneficial effect on wound healing (5)
  • Penetrating nails without cytotoxicity (5)

Refs:

  1. Flavia Franco Veiga,1,2 Maiara Ignacio Costa,1,3 Érika Seki Kioshima Cótica,1 Terezinha Inez Estivalet Svidzinski,1 and Melyssa Negri1. Propolis forthe Treatment of Onychomycosis. Journal ListIndian J Dermatolv.63(6); Nov-Dec 2018PMC6233048. PMID: 30504984
  2. Tobaldini-Valerio FK, Bonfim-Mendonça PS, Rosseto HC, Bruschi ML, Henriques M, Negri M, Silva S, Svidzinski TIe. Propolis: a potential natural product to fight Candida species infections. Future Microbiol. 2016 Aug; 11():1035-46.
  3. Capoci IR, Bonfim-Mendonça Pde S, Arita GS, Pereira RR, Consolaro ME, Bruschi ML, Negri M, Svidzinski TI. Propolis Is an Efficient Fungicide and Inhibitor of Biofilm Production by Vaginal Candida albicans. Evid Based Complement Alternat Med. 2015; 2015():287693.
  4. Tobaldini-Valerio FK, Bonfim-Mendonça PS, Rosseto HC, Bruschi ML, Henriques M, Negri M, Silva S, Svidzinski TIe. Propolis: a potential natural product to fight Candida species infections. Future Microbiol. 2016 Aug; 11():1035-46.
  5. Veiga FF, Gadelha MC, da Silva MRT, Costa MI, Kischkel B, de Castro-Hoshino LV, Sato F, Baesso ML, Voidaleski MF, Vasconcellos-Pontello V, Vicente VA, Bruschi ML, Negri M, Svidzinski TIE. Propolis Extract for Onychomycosis Topical Treatment: From Bench to Clinic. Front Microbiol. 2018; 9():779.
  6. Galletti J, Tobaldini-Valerio FK, Silva S, Kioshima ÉS, Trierveiler-Pereira L, Bruschi M, Negri M, Estivalet Svidzinski TI. Antibiofilm activity of propolis extract on Fusarium species from onychomycosis. Future Microbiol. 2017 Nov; 12():1311-1321.
  7. Siqueira AB, Gomes BS, Cambuim I, Maia R, Abreu S, Souza-Motta CM, de Queiroz LA, Porto AL. Trichophyton species susceptibility to green and red propolis from Brazil. Lett Appl Microbiol. 2009 Jan; 48(1):90-6.
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