炎症性腸病 | Inflammatory Bowel Disease
如你有此疾病,請遵照閣下醫生的完整醫療方案;而是否使用多學科復康方案前,你必須咨詢主診醫生的意見,如果閣下的主診醫生不建議您加入補充劑調理組合,請你不要使用。如果你需要尋求其他醫生作第二咨詢,閣下可聯絡我們線上<無邊界醫生>或你自己城市內的其他專業醫生的再診斷。
炎症性腸病
炎症性腸病（IBD）是一種慢性胃腸道炎症性疾病，臨床上包括克羅恩病、潰瘍性結腸炎和其他疾病[1]。IBD的腸粘膜炎症表現為腹痛、腹瀉、便血、體重減輕、中性粒細胞和巨噬細胞大量湧入，產生細胞因數、蛋白水解酶和自由基，導致炎症和潰瘍。
IBD是一種終生疾病，發生在男性和女性的生命早期。IBD的發病率和患病率在20世紀後半葉顯著增加，自21世紀初以來，IBD被認為是最流行的胃腸道疾病之一，在新興工業化國家發病率不斷上升。
克羅恩病通常累及回腸末端、盲腸、肛周區和結腸，但它可以不連續地影響腸的任何區域[6–8]。相反，潰瘍性結腸炎累及直腸，可累及部分結腸或整個結腸。克羅恩病在組織學上表現為黏膜下層增厚、跨壁炎症、裂口潰瘍和肉芽腫，而潰瘍性結腸炎的炎症僅限於黏膜和黏膜下層伴隱窩炎和隱窩膿腫[7–9]。
雖然IBD的病因尚不清楚，但近年來在闡明其發病機制方面取得了相當大的進展。研究表明，IBD的發病機制與宿主的遺傳易感性、腸道微生物群、其他環境因素和免疫异常有關。
Inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, which clinically contains Crohn's disease, ulcerative colitis, and other conditions. The inflammation of the intestinal mucosa in IBD is characterized by episodes of abdominal pain, diarrhea, bloody stools, weight loss, and the influx of neutrophils and macrophages that produce cytokines, proteolytic enzymes, and free radicals that result in inflammation and ulceration
IBD is a lifelong disease occurring early in life in both males and females. The incidence and prevalence of IBD markedly increased over the second half of the 20th century, and since the beginning of the 21st century, IBD has been considered one of the most prevalent gastrointestinal diseases with accelerating incidence in newly industrialized countries.
Crohn's disease usually involves the terminal ileum, cecum, perianal area, and colon, but it can affect any region of the intestine in a discontinuous pattern. In contrast, ulcerative colitis involves the rectum and can affect part of the colon or the entire colon in a continuous pattern. Crohn's disease exhibited histologically a thickened submucosa, transmural inflammation, fissuring ulceration, and granulomas, whereas the inflammation in ulcerative colitis is limited to the mucosa and submucosa with cryptitis and crypt abscesses.
Although the cause of IBD remains unknown, considerable progress has been made in recent years to unravel the pathogenesis of this disease. Studies have provided evidence that the pathogenesis of IBD is associated with genetic susceptibility of the host, intestinal microbiota, other environmental factors, and immunological abnormalities.
If you have this disease, please follow your doctor's complete medical plan. You must consult the attending doctor before using the multidisciplinary rehabilitation plan. If your attending doctor does not recommend you to join the supplement conditioning combination, please do not use it. If you need to seek second opinion from other doctors, you can contact our online "Doctors Without Borders", or another professional doctor in your own city.
