睡眠障碍、失調 | Sleep Disturbance, Disorder

Store/睡眠障碍、失調 | Sleep Disturbance, Disorder
睡眠障礙

睡眠障礙是一組影響睡眠-覺醒晝夜節律的疾病，導致社會和職業適應不良。現時，治療睡眠障礙的藥物種類繁多，但使用效果並不總是令人滿意。苯二氮卓類、抗抑鬱藥和抗組胺藥可能引起依賴或戒斷效應。褪黑素（N-乙醯-5-甲氧基色胺）是松果體產生的一種內源性激素，影響白天、季節節律和睡眠-覺醒週期。對褪黑素作用的研究表明，褪黑素能够使晝夜節律同步，减少緩慢睡眠的潜伏期，延長睡眠時間，提高主觀質量。此外，由於褪黑素的時間生物學效應，在其他睡眠障礙，如嗜睡，睡眠依賴性呼吸障礙和嗜睡，使用前景也被強調。現時，褪黑素是糾正日間節律和某些類型失眠的方法之一。

Ref: https://www.intechopen.com/books/melatonin-the-hor...

褪黑素

病毒感染是世界範圍內危害人類健康的疾病，每年都會導致嚴重的發病率和死亡率。由於其重要性和缺乏有效的治療方法，應進一步嘗試尋找適當的替代或補充治療。褪黑素是松果腺合成和分泌的一種多功能神經激素，在治療病毒性感染中起一定作用。關於COVID-19在全世界的致命爆發，我們决定討論褪黑素對包括COVID-19在內的各種病毒感染的作用。囙此，在這篇綜述中，我們總結了褪黑素治療病毒感染的最新證據，重點是褪黑素作用的潜在機制。

褪黑素

可能適合的補充劑支援:

  • 睡眠品質（1）
  • 系統性紅斑狼瘡（2）
  • 特應性皮炎（3）
  • 哮喘（4）
  • 類風濕性關節炎（5）
  • 多發性硬化症（6）
  • 系統性紅斑狼瘡（7）
  • 1型糖尿病（8,9）
  • 炎症性腸病（10）
  • 克羅恩病（11）
  • 潰瘍性結腸炎（12）
  • 病毒性心肌炎（13）
  • 埃博拉病毒（14）
  • 西尼羅河病毒（15）
  • 新型冠狀病毒肺炎COVID-19（16,17,18）
  • 子宮內膜異位症（19）
  • 細菌和病毒感染（20）
  • 抗癌（21,22,23,24）

Sleep disorders

Sleep disorders are a group of conditions that affect the circadian rhythm of sleep-wake, leading to social and professional maladaptation. At the moment, there is a wide range of medications aimed at the treatment of sleep disorders, but the results from their use are not always satisfactory. Benzodiazepines, antidepressants, and antihistamines may cause dependence or withdrawal effects. Melatonin (N-acetyl-5-methoxytryptamine) is an endogenous hormone produced by the pineal gland that affects intraday, seasonal rhythm, and the sleep-wake cycle. Studies of the effects of melatonin have demonstrated its ability to synchronize circadian rhythms, reduce the latency of slow sleep, increase the duration of sleep, and improve its subjective quality. This review highlights the current therapeutic possibilities of using melatonin in various sleep disorders, taking into account the mechanisms of its action. Also, the prospects of using melatonin due to its chronobiological effect in other sleep disorders, such as parasomnia, sleep-dependent respiratory disorders, and hypersomnia, are emphasized. At the moment, melatonin is one of the methods for correcting intraday rhythms and some types of insomnia.

Ref: https://www.intechopen.com/books/melatonin-the-hor...


Melatonin


Viral infections are dangerous diseases for human health worldwide, which lead to significant morbidity and mortality each year. Because of their importance and the lack of effective therapeutic approaches, further attempts should be made to discover appropriate alternative or complementary treatments. Melatonin, a multifunctional neurohormone mainly synthesized and secreted by the pineal gland, plays some roles in the treatment of viral infections. Regarding a deadly outbreak of COVID-19 across the world, we decided to discuss melatonin functions against various viral infections including COVID-19. Therefore, in this review, we summarize current evidence on melatonin therapy for viral infections with focus on possible underlying mechanisms of melatonin actions.

Possible supplements supporting:

  • Sleep quality (1)
  • Systemic lupus erythematosus (2)
  • Atopic dermatitis (3)
  • Asthma (4)
  • Rheumatoid arthritis (5)
  • Multiple sclerosis (6)
  • Systemic lupus erythematosus (7)
  • Type 1 diabetes mellitus (8,9)
  • Inflammatory bowel disease (10)
  • Crohn's disease (11)
  • Ulcerative colitis (12)
  • Viral myocarditis (13)
  • Ebola virus (14)
  • West Nile virus (15)
  • Novel coronavirus pneumonia COVID-19 (16,17,18)
  • Endometriosis (19)
  • Bacterial and Viral infections (20)
  • Anti cancers (21,22,23,24)

参考报告 / Refs：

  1. Pierre Alexis Geoffroy 1 , Bruno Etain, Jean-Arthur Micoulaud Franchi, Frank Bellivier, Philipp Ritter. Melatonin and Melatonin Agonists as Adjunctive Treatments in Bipolar Disorders. Review Curr Pharm Des. 2015;21(23):3352-8. doi: 10.2174/1381612821666150619093448.
  2. Juan R Calvo. Maria D Maldonado. The role of melatonin in autoimmune and atopic diseases. April 2016. DOI: 10.3934/molsci.2016.2.158
  3. Kimata H (2007) Elevation of salivary melatonin levels by viewing a humorous film in patients with atopic eczema. Horm Metab Res 39: 310–311.
  4. Sutherland ER, Martin RJ, Ellison MC, et al. (2002) Immunomodulatory effects of melatonin in asthma. Am J Respir Crit Care Med 166: 1055–1061.
  5. Liu X, Xu Y, Chen S, et al. (2014) Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive oxygen species and matrix metalloproteinases. Free Radic Biol Med 68: 234–246.
  6. López-González A, Álvarez-Sánchez N, Lardone PJ, et al. (2015) Melatonin treatment improves primary progressive multiple sclerosis: a case report. J Pineal Res 58: 173–177.
  7. Robeva R, Tanev D, Kirilov G, et al. (2013) Decreased daily melatonin levels in women with systemic lupus erythematosus - a short report. Balk Med J 30: 273–276.
  8. Lin GJ, Huang SH, Chen SJ, et al. (2013) Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases. Int J Mol Sci 14: 11742–11766.
  9. Lin GJ, Huang SH, Chen YW, et al. (2009) Melatonin prolongs islet graft survival in diabetic NOD mice. J Pineal Res 47: 284–292.
  10. Chojnacki C, Wisniewska-Jarosinska M, Walecka-Kapica E, et al. (2011) Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis. J Physiol Pharmacol 62: 327–334.
  11. O Iu Rakhimova. Use of melatonin in combined treatment for inflammatory bowel diseases. Comparative Study Ter Arkh. 2010;82(12):64-8. PMID: 21516743
  12. Gopabandhu Jena, MSc, MPhil, PhD, Priyanka P. Trivedi, MS(Pharm). A Review of the Use of Melatonin in Ulcerative Colitis: Experimental Evidence and New Approaches. Inflammatory Bowel Diseases, Volume 20, Issue 3, 1 March 2014, Pages 553–563, https://doi.org/10.109701.MIB.0000436962.32164.6e.
  13. Kobra Bahrampour Juybari,a,1 Mohammad Hossein Pourhanifeh,b,1 Azam Hosseinzadeh,b Karim Hemati,c and Saeed Mehrzadib, Melatonin potentials against viral infections including COVID-19: Current evidence and new findings. Journal ListElsevier Public Health Emergency Collection PMC7405774. Virus Res. 2020 Oct 2; 287: 198108.doi: 10.1016/j.virusres.2020.198108. PMCID: PMC7405774. PMID: 32768490
  14. Dun-Xian Tan 1 , Ahmet Korkmaz, Russel J Reiter, Lucien C Manchester. Ebola virus disease: potential use of melatonin as a treatment. Review J Pineal Res. 2014 Nov;57(4):381-4. doi: 10.1111/jpi.12186. Epub 2014 Oct 14. PMID: 25262626
  15. Prapimpun Wongchitrat 1, Mayuri Shukla 2, Ramaswamy Sharma 3, Piyarat Govitrapong 2,*and Russel J. Reiter 3. Review. Role of Melatonin on Virus-Induced Neuropathogenesis—A Concomitant Therapeutic Strategy to Understand SARS-CoV-2 Infection. Antioxidants 2021, 10, 47. https://doi.org/10.3390/antiox10010047
  16. Silvestri M., Rossi G.A. Melatonin: its possible role in the management of viral infections–a brief review. Ital. J. Pediatr. 2013;39:61.
  17. Shneider A., Kudriavtsev A., Vakhrusheva A. Can melatonin reduce the severity of COVID-19 pandemic? Int. Rev. Immunol. 2020;39:153–162.
  18. Reiter R.J., Ma Q. Treatment of ebola and other infectious diseases: melatonin “goes viral” Melatonin Research. 2020;1:43–57.
  19. Sumit Paul, Jalpaiguri, Partha Bhattacharya, Pramathes Das Mahapatra Snehasikta Swarnakar. Melatonin protects against endometriosis via regulation of matrix metalloproteinase-3 and an apoptotic pathway. September 2010Journal of Pineal Research 49(2):156-68. DOI: 10.1111/j.1600-079X.2010.00780.x
  20. Venkataramanujam Srinivasan 1 , Mahaneem Mohamed, Hisanori Kato. Melatonin in bacterial and viral infections with focus on sepsis: a review. Recent Pat Endocr Metab Immune Drug Discov. 2012 Jan;6(1):30-9.
    doi: 10.2174/187221412799015317. PMID: 22264213
  21. Abd El Moneim NA, El Masry H, Sorial MM. A molecular case-control study on the association of melatonin hormone and rs#10830963 single nucleotide polymorphism in its receptor MTNR1B gene with breast cancer. Middle East J cancer. 2015;6:11–20.
  22. Sigurdardottir LG, Markt SC, Rider JR, Haneuse S, Fall K, Schernhammer ES, Tamimi RM, Flynn-Evans E, Batista JL, Launer L, Harris T, Aspelund T, Stampfer MJ, et al. Urinary melatonin levels, sleep disruption, and risk of prostate cancer in elderly men. Eur Urol. 2015;67:191–194.
  23. Zhao M, Wan JY, Zeng K, Tong M, Lee AC, Ding JX, Chen Q. The reduction in circulating melatonin level may contribute to the pathogenesis of ovarian cancer: A retrospective study. J Cancer. 2016;7:831–836.
  24. Wang YM, Jin BZ, Ai F, Duan CH, Lu YZ, Dong TF, Fu QL. The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: A meta-analysis of randomized controlled trials. Cancer Chemother Pharmacol. 2012;69:1213–1220.

Display prices in:HKD