The number of people with diabetes worldwide was 382 million in 2013 and nearly 592 million people are estimated to be diabetic by 2035. Diabetes
is one of the most common metabolic disorders, characterized by defective secretion of insulin. Immune mediated destruction of pancreatic b-cells leads to insulin deficiency and eventually to type I diabetes, while type II diabetes is characterized by insulin resistance and relative deficiency in insulin signaling. Hyperglycemia is recognized as a major responsible factor for the development of diabetic complications. Diabetes involves many overlapping and interrelated pathways that results in potentially blinding complications like diabetic retinopathy and macular edema. Diabetic retinopathy (DR) is the most widespread microvascular complication of diabetes and a major cause of vision loss worldwide. Globally, there are approximately 93 million people with DR, 17 million with proliferative DR, 21 million with diabetic macular edema, and 28 million with VTDR. A new systematic review of 35 population-based studies has revealed that the prevalence of diabetic retinopathy, proliferative diabetic retinopathy (PDR), and diabetic macular edema (DME) among diabetic patients is 34.6%, 7.0%, and 6.8%, respectively. It is characterized by the increased development of distinct morphological abnormalities in the retinal microvasculature that either remains stable or progresses to diabetic macular edema or proliferative diabetic retinopathy, which are leading causes of severe visual impairment in working-age adults especially in industrialized countries. The severity of diabetic retinopathy ranges from nonproliferative and preproliferative to more severely proliferative diabetic retinopathy, in which the abnormal growth of new vessels occurs. A number of clinical trials on the prevention or treatment of diabetic retinopathy and diabetic macular edema (DME) are in progress.
If you have this disease, please follow your doctor's complete medical plan. You must consult the attending doctor before using the multidisciplinary rehabilitation plan. If your attending doctor does not recommend you to join the supplement conditioning combination, please do not use it. If you need to seek second opinion from other doctors, you can contact our online "Doctors Without Borders", or another professional doctor in your own city.