If you have this disease, please follow your doctor's complete medical plan. You must consult the attending doctor before using the multidisciplinary rehabilitation plan. If your attending doctor does not recommend you to join the supplement conditioning combination, please do not use it. If you need to seek second opinion from other doctors, you can contact our online "Doctors Without Borders", or another professional doctor in your own city.
This pricing is for reference only. Doctors need to follow the immediate situation (for example, whether there is proliferation or invasion of other organs) to implement a more accurate multi-disciplinary medical scheme, and the cost will increase or decrease accordingly. All medical expenses only need to be paid directly to the relevant hospitals when they go to see a doctor. This platform will not participate in collecting patients' money. Please note. Under the normal experience, the single tumor ablation with nanoknife is about RMB150,000, and the two tumor ablation is about RMB200,000. Warm tips: if overseas patients come to mainland China for treatment, they must be accompanied by their families. Additional arrangements are also required for the expenses of hotels, meals, transportation, etc. during the treatment and observation for one to two weeks.
Nanoknife tumor ablation technology
Nanoknife tumor ablation technology, originated from irreversible electroporation technology, is a new non thermal tumor ablation technology. Through the application of high-voltage short pulse DC penetration technology, the transmembrane potential can be changed to increase the permeability of cell membrane, resulting in the formation of lipid bilayer structure of cell membrane and irreversible electroporation at nanometer level, which can more accurately induce apoptosis in the ablation area and promote the normal group The regeneration and repair of the tumor can completely dissolve the tumor and will not cause irreversible damage to other important tissues in the ablation area. It is suitable for liver, lung, kidney, pancreas, prostate and other solid tumors, especially for tumors near the hilar region, gallbladder bile duct, pancreas, urinary canal and nerve, and its advanced, safe and effective has been filled. Sub validation. By the end of 2015, nearly 100 sets of the equipment have been installed in many European and American countries, and many domestic teaching hospitals have carried out animal experimental research and clinical verification, and its safety and effectiveness have been highly praised by clinical experts at home and abroad.
Advantages of nanoknife tumor ablation technology:
1) Short ablation time: in the treatment of solid tumors with a diameter of about 3cm, the nano knife tumor treatment generally only needs 90 100 millisecond ultrashort pulses. The treatment time of one group was less than one minute. Therefore, even if there are three or four overlapping ablation areas, the whole ablation time will not exceed 5 minutes. After treatment, if you are in good health, you can be discharged on the same day or the next day.
2) The blood vessels, bile ducts and nerves in the treatment area were preserved
The traditional way of ablation is to make proteins denatured by heating or cooling, so that all kinds of proteins and DNA are destroyed, and the structure of the disease area will be damaged and cannot be repaired. Another characteristic of nanoknife ablation technology is that it can protect the important tissue structure in the ablation area. In all liver tissues treated by nanoknife, its important structures, such as hepatic artery, hepatic vein, portal vein and intrahepatic bile duct, will not cause permanent irreversible damage, so they can be well protected.
The principle of nanoknife is that its irreversible electroporation technology only destroys the cell membrane and does not affect other structures or molecules in the tissue. Each layer of vascular wall is composed of endothelial cells, smooth muscle cells, connective tissue, elastin, collagen and other extracellular matrix components. Although irreversible electroporation can also affect vascular smooth muscle cells to a certain extent, its mechanism is only to destroy the cell membrane, only to affect the cells, so it will not destroy other types of molecules in the tissue architecture, and still maintain the integrity of connective tissue and vascular extracellular matrix, maintaining the basic vascular architecture. In addition, extracellular matrix also provides a good scaffold for the formation of new and healthy tissues. Therefore, in the treatment of tumor around blood vessels, bile ducts and nerves, microsecond electric pulses are applied to cells to form permanent nanoscale gaps in the phospholipid bilayer of cell membrane, leading to cell apoptosis; after the end of treatment, the blood vessels, bile ducts and nerves in the ablation area are still intact. For bile duct, the structure of bile duct will not be affected because of more collagen connective tissue and elastic fibers and lack of normal cell membrane which can produce nano space by irreversible electroporation.
In addition, the technique will not cause irreversible damage to the nerve in the ablation area, because the structure of its protein composition is not affected by irreversible electroporation ablation, so it will not affect the integrity of basement membrane or nerve endomembrane; and the integrity of nerve endomembrane and nerve bundle membrane also provides conditions for nerve regeneration. At the same time, although the small nerve vessels will be slightly damaged, they can recover quickly and ensure the integrity of their endothelium, thus protecting the microvascular system in the ablation area and increasing the possibility of nerve regeneration.
3) The influence of unheated pool effect (some are called heat sink effect) or cold pool effect
Nanoknife ablation is mainly through the pulse impact through the cell membrane, in this process will not produce heat, also will not be affected by other external temperature. Traditional thermal ablation or cold ablation, once there are large blood vessels in the ablation area, the heat will be taken away by the blood flow, resulting in incomplete peripheral ablation, which is easy to cause recurrence, and nanoknife can avoid this problem.
4) The treatment was thorough and the treatment boundary was clear
Another advantage of nanoknife ablation is that it can completely ablate the tumor regardless of its location, size and shape. In addition, the ablation area of nanoknife has a clear boundary, and the boundary thickness is only 1-2 cell units. The treatment area and non treatment area are distinct, so the effectiveness, treatment results and follow-up of nanoknife treatment can be more accurately judged and evaluated. In other ablation methods, such as radiofrequency or microwave, there will be a "gray area" at the edge of the ablation area, that is, there are a large range of tumor cells that are not completely inactivated in the most peripheral area of the ablation area. This is one of the main hidden dangers of tumor recurrence in the future, which does not exist in nanoknife treatment.
5) Normal function of the treated area was restored
The traditional ablation mode is to denature the tissue protein through temperature, and then coagulate necrosis occurs. After necrosis, the tissue structure in the whole ablation area no longer exists. Then, the necrotic tissue which is toxic to the organs is left, and the normal function can not be restored. On the contrary, nanoknife therapy can induce apoptosis of tumor cells. One of the advantages of apoptosis is that it can use immunity to promote cell death. The human body will recognize cell apoptosis as a normal process of cell death, and then remove the apoptotic tissue through cell phagocytosis to promote the regeneration and repair of normal tissue.
6) The effect process can be monitored in real time
Nanoknife therapy can be guided and monitored by ultrasound, CT and Mr. With the aid of imaging equipment, the positioning of nanoknife probe, the ablation process of target area and the size of the final ablation area can be monitored in real time, and the accuracy of the ablation area boundary in the image is comparable to that in histology. The size deviation between the ablation area monitored by ultrasound or CT and the real ablation area measured by pathological analysis is only a few millimeters. Therefore, the image monitoring accuracy of nanoknife ablation is very high. The image can also clearly show the remaining cancer cells that have not been ablated, so that doctors can ablate them again. In addition, real-time monitoring also allows doctors to observe the changes of tissue around the ablation area, so as to infer the possibility of complications, ensure the safety of patients and help them recover quickly after surgery.
7) Nanoknife can adapt to more complex conditions
In traditional ablation therapy, once the tumor is close to the big blood vessels, bile duct, pancreatic duct, hepatic portal vein and other dangerous areas, it can not be treated safely and effectively. In addition, for prostate tumors or tumors near the spine, ablation is easy to lead to the loss of sexual function or nerve damage and paralysis. Because nanoknife will not cause irreversible damage to the pipeline structure and nerve, it can provide safe, accurate and effective treatment for the above mentioned cases, and has an irreplaceable role for such patients.
