脫髮、稀髮 | Hair Loss, Thin Hair

Store/脫髮、稀髮 | Hair Loss, Thin Hair

脫髮、稀髮

多囊卵巢綜合征（PCOS）是女性最常見的內分泌疾病，臨床表現多樣。從青春期到更年期，這些婦女可能表現出生殖、皮膚、代謝、心理或腫瘤的影響。常見的皮膚病表現包括多毛、痤瘡、脫髮或黑棘皮病。有這些皮膚病表現的婦女必須評估多囊卵巢綜合征。一個多學科的團隊方法，包括生殖內分泌學家，皮膚科醫生，心理學家/精神病學家，營養師，有時還包括减肥外科醫生，應採取長期管理這些患者。除非代謝和潜在的內分泌紊亂得到糾正，同時採取生活方式的改變，美容治療只能暫時緩解。 (1)

局部外塗或內服褪黑素、肌醇與脫髮的關係:

  • 顯著降低脫髮的嚴重程度(2)
  • 女性脫髮率顯著减少(2)
  • 頭皮脂溢和脂溢性皮炎减少(2)
  • 雄激素性脫髮治療選擇(2)
  • 顯著增加雄激素性脫髮婦女的枕毛生長發率(3)
  • 額毛顯著增加(3)
  • 脫髮减少(4)
  • PCOS症狀幾乎全部消失(4)
  • 皮膚高雄激素血症幾乎全部消失(4)



Hair Loss, Thin Hair

Polycystic ovarian syndrome (PCOS) is the commonest endocrine disorder in women having wide range of clinical manifestation. These women may present with reproductive, dermatological, metabolic, psychological, or neoplastic implications from adolescence to menopause. The common dermatological manifestations include hirsutism, acne, alopecia, or acanthosis nigricans. Women presenting with these dermatological manifestations must be evaluated for PCOS. A multidisciplinary team approach involving a reproductive endocrinologist, dermatologist, psychologist/psychiatrist, dietician, and sometimes a bariatric surgeon should be undertaken for long-term management of these patients. Unless metabolic and underlying endocrinal disturbances arecorrected and simultaneous life-style modification is adopted, cosmetic treatment would give only temporary relief.(1)

The relationship between melatonin, inositol and alopecia

  • Significantly reduced the severity of alopecia (2)
  • Significant decrease of hair loss rate in women (2)
  • Reduction of seborrhea and seborrheic dermatitis of scalp (2)
  • Treatment options for androgenic alopecia (2)
  • Significant increase of occipital hair growth rate in androgenic alopecia women (3)
  • The number of frontal hairs increased significantly (3)
  • Reduced hair loss (4)
  • Almost all PCOS symptoms disappeared (4)
  • Skin hyperandrogenemia almost disappeared (4)

Refs:
  1. Shalini Gainder and Bharti Sharma. Update on Management of Polycystic Ovarian Syndrome for Dermatologists. Journal ListIndian Dermatol Online Jv.10(2); Mar-Apr 2019PMC6434760. Indian Dermatol Online J. 2019 Mar-Apr; 10(2): 97–105. doi: 10.4103/idoj.IDOJ_249_17. PMCID: PMC6434760
    PMID: 30984582
  2. Tobias W Fischer, Ralph M Trüeb,1 Gabriella Hänggi,2 Marcello Innocenti,3 and Peter Elsner4. Topical Melatonin for Treatment of Androgenetic Alopecia. Journal ListInt J Trichologyv.4(4); Oct-Dec 2012PMC3681103. Int J Trichology. 2012 Oct-Dec; 4(4): 236–245. doi: 10.4103/0974-7753.111199. PMCID: PMC3681103. PMID: 23766606
  3. T W Fischer 1 , G Burmeister, H W Schmidt, P Elsner. Melatonin increases anagen hair rate in women with androgenetic alopecia or diffuse alopecia: results of a pilot randomized controlled trial. Clinical Trial. Br J Dermatol. 2004 Feb;150(2):341-5. doi: 10.1111/j.1365-2133.2004.05685.x. PMID: 14996107
  4. Giuseppe Gullo. Inositol and FSH: A new frontier for the androgenetic alopecia treatment in PCOS.Polycystic Ovarian Syndrome Conference. November 16-18, 2015 Seattle, USA, University of Palermo cum laude, Italy

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