草酸鈣結晶 | Calcium Oxalate Crystal

Store/草酸鈣結晶 | Calcium Oxalate Crystal

草酸鈣晶體

腎結石的常見病因包括草酸鈣結晶、體內尿酸水准高和檸檬酸鹽含量低。研究發現，尿草酸的少量减少與草酸鈣結石的形成顯著减少有關；囙此，建議避免食用富含草酸的食物，如黃瓜、青椒、紅菜頭根、菠菜、大豆、巧克力、大黃、爆米花和甘薯。腎結石多累及腎、輸尿管、尿道等部位。更重要的是，腎結石是一種復發性疾病，據報導草酸鈣晶體的終生復發風險高達50%。發生腎結石的草酸鈣是印度報導的最常見的結石。因此，由於腎結石疾病，現在在印度和世界其他地區發現的心臟病的發病率更高。腎結石降低了體內礦物質的含量，减少了骨骼形成的必要元素。與正常人相比，患者檢測到血液中的高血脂水准可能有發生腎結石的傾向。患者建議服用低脂飲食和天然植物纖維及其草藥。中藥與對症治療相結合是一個很好的方法，可以消除所有與腎結石有關的併發症。 (1)

溶解草酸鈣結晶的部份研究:

  • 降低游離鈣(2)
  • 降低體外結石生長速率(2)
  • 對一水草酸鈣生長和聚集的强烈抑制作用(3)
  • 防止腎結石形成(3)
  • 可能是治療尿石症有吸引力的療法(3)
  • 抑制二水草酸鈣晶體向一水草酸鈣晶體的轉化(4)
  • 可以作為一種潜在的抗石藥(4)
  • 溶解草酸鈣結晶(5)


Calcium Oxalate Crystal

Kidney stones are the most commonly seen in both males and females. Obesity is one of the major risk factor for developing stones. The common cause of kidney stones include the crystals of calcium oxalate, high level of uric acid and low amount of citrate in the body. A small reduction in urinary oxalate has been found to be associated with significant reduction in the formation of calcium oxalate stones; hence, oxalate-rich foods like cucumber, green peppers, beetroot, spinach, soya bean, chocolate, rhubarb, popcorn, and sweet potato advised to avoid. Mostly kidney stone affect the parts of body like kidney ureters and urethra. More important, kidney stone is a recurrent disorder with life time recurrence risk reported to be as high as 50% by calcium oxalate crystals. Calcium oxalate occurred kidney stones is the most common stone reported in India. Therefore, due to disease of kidney stones there is a higher chance of developing heart diseases which are now detected in India and the rest World. Kidney stones forms lower the minerals in the body as well as reduced the essential element for bone formation. The patients detects higher lipid level in the blood may have the tendency to develop kidneys stones as compared to normal individuals. The patients have advice to take low fat diet and fibers of natural occurring plants and its herbal medicines. The combination of herbal medicines with allopathic treatment have a great idea to get rid all the complications related to kidney stones.(1)


Studies on the dissolution of calcium oxalate crystals

  • Reducing free calcium (2)
  • Reducing the growth rate of calculus in vitro (2)
  • Strong inhibition on growth and aggregation of calcium oxalate monohydrate (3)
  • Prevention of renal calculi (3)
  • May be an attractive treatment for urolithiasis (3)
  • Inhibiting the transformation of calcium oxalate dihydrate crystal to calcium oxalate monohydrate crystal (4)
  • It can be used as a potential anti stone drug (4)
  • Dissolution and crystallization of calcium oxalate (5)

Refs:
  1. https://medcraveonline.com/UNOAJ/UNOAJ-07-00247
  2. N.K. Saw, K. Chow, P.N. Rao, J.P. Kavanagh. Effects of Inositol Hexaphosphate (Phytate) on Calcium Binding, Calcium Oxalate Crystallization and In Vitro Stone Growth. July 2007The Journal of Urology 177(6):2366-70. DOI: 10.1016/j.juro.2007.01.113
  3. De Bellis R, Piacentini MP, Meli MA, Mattioli M, Menotta M, Mari M, et al. (2019) In vitro effects on calcium oxalate crystallization kinetics and crystal morphology of an aqueous extract from Ceterach officinarum: Analysis of a potential antilithiatic mechanism. PLoS ONE 14(6): e0218734. https://doi.org/10.1371/journal.pone.0218734
  4. Jia-Yun Chen, Xin-Yuan Sun, Jian-Ming Ouyang, "Modulation of Calcium Oxalate Crystal Growth and Protection from Oxidatively Damaged Renal Epithelial Cells of Corn Silk Polysaccharides with Different Molecular Weights", Oxidative Medicine and Cellular Longevity, vol. 2020, Article ID 6982948, 19 pages, 2020. https://doi.org/10.1155/2020/6982948
  5. Shouwu Guo, Michael D. Ward, Jeffrey A. Wesson. Direct Visualization of Calcium Oxalate Monohydrate Crystallization and Dissolution with Atomic Force Microscopy and the Role of Polymeric Additives. Langmuir 2002, 18, 11, 4284–4291. Publication Date:May 1, 2002. https://doi.org/10.1021/la011754+
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