唇瘡 痱滋 | Aphthous Ulcer

蜂膠

蜂膠是一種天然的樹脂混合物,由蜜蜂從植物的某些部位、芽和分泌物中選取物質製成。由於蜂膠的蠟質和機械特性,蜜蜂在建造和修理蜂箱時使用蜂膠來密封開口和裂縫,平滑內壁,並作為抵禦外來入侵物(如蛇、蜥蜴等)或抵禦風雨等風化威脅的保護屏障。蜜蜂採集的蜂膠來自不同的植物,在溫帶氣候區主要來自楊樹。蜂膠現時的抗菌應用包括感冒綜合征(上呼吸道感染、普通感冒和流感樣感染)、傷口癒合、燒傷、痤瘡、單純皰疹和生殖器以及神經性皮炎的治療。

高濃参碱蜂膠液

特色: 蜂膠含黃酮類化合物、多種天然胺基酸、維他命和人體必需的微量元素等等,有助迅速癒合傷口、促進細胞再生。長期食用蜂膠亦有助強身健體。

可能適合的補充劑支援:

唇瘡 痱滋(1)、胃痛(2)、喉嚨痛(3)、久咳(4)、上呼吸道感染(5)、抗微生物(6,8)、抗真菌(7)、抗原蟲(9,10)、抗肿瘤活性(11,12,13,14,)、哮喘(15)、普通感冒(16)、 流感样感染(17)、傷口癒合(18)、燒傷(19)、痤瘡(20)單純皰疹(21)癌症(22,23)灰甲(24) 寄生蟲(25,26,27)


Propolis

Propolis is a natural resin mixture, which is made by bees from certain parts of plants, buds and secretions. Due to the wax and mechanical properties of propolis, bees use propolis to seal openings and cracks, smooth the inner wall, and act as a protective barrier against foreign invaders (such as snakes, lizards, etc.) or weathering threats such as wind and rain when building and repairing beehives. Bees collect propolis from different plants, mainly from poplar in temperate climate. The current antibacterial applications of propolis include the treatment of cold syndrome (upper respiratory tract infection, common cold and influenza like infection), wound healing, burns, acne, herpes simplex and genitalia, and neurodermatitis.

High Concentration Matrine Propolis

Features: Propolis contains flavonoids, a variety of natural amino acids, vitamins and trace elements necessary for human body, etc. it helps to heal wounds quickly and promote cell regeneration. Long term consumption of propolis also helps to strengthen the body.

Possible supplements supporting:

Aphthous Ulcer (1), stomachache (2), sore throat (3), chronic cough (4), upper respiratory tract infection (5), anti microbial (6,8), anti fungal (7), antigen worm (9,10), anti-tumor activity (11,12,13,14,), asthma (15), common cold (16), influenza like infection (17), wound healing (18), burn (19), acne (20), herpes simplex (21) Cancer disease (22,23), Onychomycosis(24), Parasites (25,26,27).


參考研究 Refs:

  1. Nachum Samet 1 , Caroline Laurent, Srinivas M Susarla, Naama Samet-Rubinsteen The effect of bee propolis on recurrent aphthous stomatitis: a pilot study Clin Oral Investig . 2007 Jun;11(2):143-7. doi: 10.1007/s00784-006-0090-z. Epub 2007 Feb 7. PMID: 17285269 . DOI: 10.1007/s00784-006-0090-z
  2. Luísa Silva, Priscila de Souza, Soad Khalil AL Jaouni, Steve Harakeh. Propolis and Its Potential to Treat Gastrointestinal DisordersMarch 2018, Evidence-based Complementary and Alternative Medicine 2018(7):1-12, DOI: 10.1155/2018/2035820
  3. Vijay D. Wagh, Propolis: A Wonder Bees Product and Its Pharmacological Potentials. Adv Pharmacol Sci. 2013; 2013: 308249. Published online 2013 Dec 9. doi: 10.1155/2013/308249. PMCID: PMC3872021. PMID: 24382957
  4. Ibrahim Alfahdawi. Propolis In Medicine & Dentistry. April 2017. Edition: 1. Publisher: LAMBERT Academic Publishing. Editor: Dr. Wolfgang Philipp Muller
  5. Vijay D. Wagh, "Propolis: A Wonder Bees Product and Its Pharmacological Potentials", Advances in Pharmacological and Pharmaceutical Sciences, vol. 2013, Article ID 308249, 11 pages, 2013. https://doi.org/10.1155/2013/308249
  6. Nilesh Kumar*, Mueen Ahmad K. K., Raman Dang and Ahmed Husain. Department of Pharmacognosy, Al-Ameen College of Pharmacy, Hosur road, Bangalore. Antioxidant and antimicrobial activity of Propolis from Tamil Nadu zone. Article Number - C57754015645.Vol.2(12), pp. 361-364 , December 2008. https://doi.org/10.5897/JMPR.9000208
  7. Ayşe Nedret Koç, Sibel Silici, Filiz Kasap, Hatice Tuna Hörmet-Öz, Hikmet Mavus-Buldu, and Barış Derya Ercal. Antifungal Activity of the Honeybee Products Against Candida spp. and Trichosporon spp. Journal of Medicinal FoodVol. 14, No. 1-2 Full Communications. Published Online:18 Jan 2011. https://doi.org/10.1089/jmf.2009.0296
  8. J M Grange MSc MD, R W Davey, MFHom. Antibacterial Properties of Propolis (Bee Glue) . https://doi.org/10.1177/014107689008300310
  9. Kelly Salomão, Eniuce M. de Souza, Andrea Henriques-Pons, Helene S. Barbosa, Solange L. de Castro, "Brazilian Green Propolis: Effects In Vitro and In Vivo on Trypanosoma cruzi", Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 185918, 11 pages, 2011. https://doi.org/10.1093/ecam/nep014
  10. Torres, D. ; Hollands, I. ; Palacios, E. Effect of an alcoholic extract of propolis on the in vitro growth of Giardia lamblia. Journal article : Revista Cubana de Ciencias Veterinarias 1990 Vol.21 No.1 pp.15-19
  11. Mok-RyeonAhnaKazuhiroKunimasab ToshiroOhtab ShigenoriKumazawaa MiyaKamihiraaKazuhikoKajib YoshihiroUtoc HitoshiHoric HidekoNagasawad TsutomuNakayamaa. Suppression of tumor-induced angiogenesis by Brazilian propolis: Major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation. Cancer Letters Volume 252, Issue 2, 18 July 2007, Pages 235-243. https://doi.org/10.1016/j.canlet.2006.12.039
  12. Oršolić, Nada ; Bendelja, Krešo ; Brbot– ; Šaranović, Ana ; Bašić, Ivan. Effect of caffeic acid phenethyl ester and caffeic acid, an antioxidant from propolis, on inducing apoptosis in HeLa human cervical carcinoma and Chinese hamster lung V79 fibroblast cells. Periodicum biologorum (0031-5362) 106 (2004); 367-372
  13. Chemical diversity of propolis makes it a valuable source of new biologically active compounds. Journal of ApiProduct and ApiMedical Science 1 (2): 23 - 28 (2009). DOI 10.3896/IBRA.4.01.2.01.
  14. Nada Oršolić, Svjetlana Terzić, Željko Mihaljević, Lidija Šver, Ivan Bašić. Effects of Local Administration of Propolis and Its Polyphenolic Compounds on Tumor Formation and Growth. 2005 Volume 28 Issue 10 Pages 1928-1933. DOI https://doi.org/10.1248/bpb.28.1928
  15. M T Khayyal 1 , M A el-Ghazaly, A S el-Khatib, A M Hatem, P J F de Vries, S el-Shafei, M M Khattab. A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients. . 2003 Feb;17(1):93-102. doi: 10.1046/j.1472-8206.2003.00117.x. PMID: 12588635
  16. A. Ohkuma, T. Kanno, T. Asama, S. Doi-Takaki. Effect of dietary supplement containing brazilian propolis on the common cold. January 2010. Pharmacometrics 79(3):43-48.
  17. Ali Farid M. Ali, Ermelando V. Cosmi, Sanaa M. Al and Laila Farid. Bee propolis as a new modality for treatment of H1N1 Influenza. J Am Sci 2013;9(34):261-264]. (ISSN: 1545-1003).http://www.jofamericanscience.org. 34
  18. AhmadOryana, EsmatAlemzadehb, AliMoshiric. Potential role of propolis in wound healing: Biological properties and therapeutic activities. Biomedicine & Pharmacotherapy. Volume 98, February 2018, Pages 469-483. https://doi.org/10.1016/j.biopha.2017.12.069
  19. Paweł Olczyk, 1 , * Robert Koprowski, 2 Justyna Kaźmierczak, 3 Lukasz Mencner, 3 Robert Wojtyczka, 4 Jerzy Stojko, 5 Krystyna Olczyk, 3 and Katarzyna Komosinska-Vassev 3 Bee Pollen as a Promising Agent in the Burn Wounds Treatment. Journal ListEvid Based Complement Alternat Medv.2016; 2016. PMC4887649 Evid Based Complement Alternat Med. 2016; 2016: 8473937. Published online 2016 May 18. doi: 10.1155/2016/8473937 PMCID: PMC4887649 PMID: 27293466.
  20. Basma M Mohammad Ali1, Naglaa F Ghoname2, Abeer A Hodeib MD 1, Marwa A Elbadawy1
    Department of Dermatology and Venereology, Tanta University, Tanta, Egypt. Significance of topical propolis in the treatment of facial acne vulgaris. DOI: 10.4103/1110-6530.162468
  21. Silke Nolkemper,Jürgen Reichling,Karl Heinz Sensch,Paul Schnitzler September 2009. Mechanism of herpes simplex virus type 2 suppression by propolis extracts. 17(2):132-8. Phytomedicine: International Journal of Phytotherapy and PhytopharmacologyI: 10.1016/j.phymed.2009.07.006
  22. Patricia Vit, Fazlul Huq, Ortrud Monika Barth, Mercedes Campo. Use of Propolis in Cancer Research. April 2015.British Journal of Medicine and Medical Research 8(2):88-109. DOI: 10.9734/BJMMR/2015/16216
  23. Pongsathon Premratanachai1 and Chanpen Chanchao2,. Review of the anticancer activities of bee products. Asian Pac J Trop Biomed. 2014 May; 4(5): 337–344. doi: 10.12980/APJTB.4.2014C1262. PMCID: PMC3985046. PMID: 25182716.
  24. Flavia Franco Veiga,1,2 Maiara Ignacio Costa,1,3 Érika Seki Kioshima Cótica,1 Terezinha Inez Estivalet Svidzinski,1 and Melyssa Negri1.Propolis for the Treatment of Onychomycosis. Journal List. Indian J Dermatol. v.63(6); Nov-Dec 2018. PMC6233048. Indian J Dermatol. 2018 Nov-Dec; 63(6): 515–517. doi: 10.4103/ijd.IJD_365_17.PMID: 30504984
  25. C Miyares 1 , I Hollands, C Castañeda, T González, T Fragoso, R Currás, C Soria. Clinical trial with a preparation based on propolis "propolisina" in human giardiasis. Clinical Trial Acta Gastroenterol Latinoam. 1988;18(3):195-201. PMID: 3077894
  26. Jéssica Rebouças-Silva,1,2 Fabiana S. Celes,1 Jonilson Berlink Lima,3 Hernane S. Barud ,4,5 Camila I. de Oliveira ,1 Andresa A. Berretta ,6,7 and Valéria M. Borges 1,2. Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts. Evidence-Based Complementary and Alternative Medicine / 2017 / Article. Research Article | Open Access
    Volume 2017 |Article ID 6067172 | https://doi.org/10.1155/2017/6067172
  27. S.F. Freitas. L Shinohara. José Maurício Sforcin. In vitro effects of propolis on Giardia duodenalis trophozoites. March 2006Phytomedicine 13(3):170-5. DOI: 10.1016/j.phymed.2004.07.008


褪黑素

病毒感染是世界範圍內危害人類健康的疾病,每年都會導致嚴重的發病率和死亡率。由於其重要性和缺乏有效的治療方法,應進一步嘗試尋找適當的替代或補充治療。褪黑素是松果腺合成和分泌的一種多功能神經激素,在治療病毒性感染中起一定作用。關於COVID-19在全世界的致命爆發,我們决定討論褪黑素對包括COVID-19在內的各種病毒感染的作用。囙此,在這篇綜述中,我們總結了褪黑素治療病毒感染的最新證據,重點是褪黑素作用的潜在機制。

褪黑素

可能適合的補充劑支援:

  • 睡眠品質(1)
  • 系統性紅斑狼瘡(2)
  • 特應性皮炎(3)
  • 哮喘(4)
  • 類風濕性關節炎(5)
  • 多發性硬化症(6)
  • 系統性紅斑狼瘡(7)
  • 1型糖尿病(8,9)
  • 炎症性腸病(10)
  • 克羅恩病(11)
  • 潰瘍性結腸炎(12)
  • 病毒性心肌炎(13)
  • 埃博拉病毒(14)
  • 西尼羅河病毒(15)
  • 新型冠狀病毒肺炎COVID-19(16,17,18)
  • 子宮內膜異位症(19)
  • 細菌和病毒感染(20)
  • 抗癌(21,22,23,24)

Melatonin

Viral infections are dangerous diseases for human health worldwide, which lead to significant morbidity and mortality each year. Because of their importance and the lack of effective therapeutic approaches, further attempts should be made to discover appropriate alternative or complementary treatments. Melatonin, a multifunctional neurohormone mainly synthesized and secreted by the pineal gland, plays some roles in the treatment of viral infections. Regarding a deadly outbreak of COVID-19 across the world, we decided to discuss melatonin functions against various viral infections including COVID-19. Therefore, in this review, we summarize current evidence on melatonin therapy for viral infections with focus on possible underlying mechanisms of melatonin actions.

Possible supplements supporting:

  • sleep quality (1)
  • Systemic lupus erythematosus (2)
  • Atopic dermatitis (3)
  • Asthma (4)
  • Rheumatoid arthritis (5)
  • Multiple sclerosis (6)
  • Systemic lupus erythematosus (7)
  • Type 1 diabetes mellitus (8,9)
  • Inflammatory bowel disease (10)
  • Crohn's disease (11)
  • Ulcerative colitis (12)
  • Viral myocarditis (13)
  • Ebola virus (14)
  • West Nile virus (15)
  • Novel coronavirus pneumonia COVID-19 (16,17,18)
  • Endometriosis (19)
  • Bacterial and Viral infections (20)
  • Anti cancers (21,22,23,24)

参考报告 / Refs:

  1. Pierre Alexis Geoffroy 1 , Bruno Etain, Jean-Arthur Micoulaud Franchi, Frank Bellivier, Philipp Ritter. Melatonin and Melatonin Agonists as Adjunctive Treatments in Bipolar Disorders. Review Curr Pharm Des. 2015;21(23):3352-8. doi: 10.2174/1381612821666150619093448.
  2. Juan R Calvo. Maria D Maldonado. The role of melatonin in autoimmune and atopic diseases. April 2016. DOI: 10.3934/molsci.2016.2.158
  3. Kimata H (2007) Elevation of salivary melatonin levels by viewing a humorous film in patients with atopic eczema. Horm Metab Res 39: 310–311.
  4. Sutherland ER, Martin RJ, Ellison MC, et al. (2002) Immunomodulatory effects of melatonin in asthma. Am J Respir Crit Care Med 166: 1055–1061.
  5. Liu X, Xu Y, Chen S, et al. (2014) Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive oxygen species and matrix metalloproteinases. Free Radic Biol Med 68: 234–246.
  6. López-González A, Álvarez-Sánchez N, Lardone PJ, et al. (2015) Melatonin treatment improves primary progressive multiple sclerosis: a case report. J Pineal Res 58: 173–177.
  7. Robeva R, Tanev D, Kirilov G, et al. (2013) Decreased daily melatonin levels in women with systemic lupus erythematosus - a short report. Balk Med J 30: 273–276.
  8. Lin GJ, Huang SH, Chen SJ, et al. (2013) Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases. Int J Mol Sci 14: 11742–11766.
  9. Lin GJ, Huang SH, Chen YW, et al. (2009) Melatonin prolongs islet graft survival in diabetic NOD mice. J Pineal Res 47: 284–292.
  10. Chojnacki C, Wisniewska-Jarosinska M, Walecka-Kapica E, et al. (2011) Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis. J Physiol Pharmacol 62: 327–334.
  11. O Iu Rakhimova. Use of melatonin in combined treatment for inflammatory bowel diseases. Comparative Study Ter Arkh. 2010;82(12):64-8. PMID: 21516743
  12. Gopabandhu Jena, MSc, MPhil, PhD, Priyanka P. Trivedi, MS(Pharm). A Review of the Use of Melatonin in Ulcerative Colitis: Experimental Evidence and New Approaches. Inflammatory Bowel Diseases, Volume 20, Issue 3, 1 March 2014, Pages 553–563, https://doi.org/10.109701.MIB.0000436962.32164.6e.
  13. Kobra Bahrampour Juybari,a,1 Mohammad Hossein Pourhanifeh,b,1 Azam Hosseinzadeh,b Karim Hemati,c and Saeed Mehrzadib, Melatonin potentials against viral infections including COVID-19: Current evidence and new findings. Journal ListElsevier Public Health Emergency Collection PMC7405774. Virus Res. 2020 Oct 2; 287: 198108.doi: 10.1016/j.virusres.2020.198108. PMCID: PMC7405774. PMID: 32768490
  14. Dun-Xian Tan 1 , Ahmet Korkmaz, Russel J Reiter, Lucien C Manchester. Ebola virus disease: potential use of melatonin as a treatment. Review J Pineal Res. 2014 Nov;57(4):381-4. doi: 10.1111/jpi.12186. Epub 2014 Oct 14. PMID: 25262626
  15. Prapimpun Wongchitrat 1, Mayuri Shukla 2, Ramaswamy Sharma 3, Piyarat Govitrapong 2,*and Russel J. Reiter 3. Review. Role of Melatonin on Virus-Induced Neuropathogenesis—A Concomitant Therapeutic Strategy to Understand SARS-CoV-2 Infection. Antioxidants 2021, 10, 47. https://doi.org/10.3390/antiox10010047
  16. Silvestri M., Rossi G.A. Melatonin: its possible role in the management of viral infections–a brief review. Ital. J. Pediatr. 2013;39:61.
  17. Shneider A., Kudriavtsev A., Vakhrusheva A. Can melatonin reduce the severity of COVID-19 pandemic? Int. Rev. Immunol. 2020;39:153–162.
  18. Reiter R.J., Ma Q. Treatment of ebola and other infectious diseases: melatonin “goes viral” Melatonin Research. 2020;1:43–57.
  19. Sumit Paul, Jalpaiguri, Partha Bhattacharya, Pramathes Das Mahapatra Snehasikta Swarnakar. Melatonin protects against endometriosis via regulation of matrix metalloproteinase-3 and an apoptotic pathway. September 2010Journal of Pineal Research 49(2):156-68. DOI: 10.1111/j.1600-079X.2010.00780.x
  20. Venkataramanujam Srinivasan 1 , Mahaneem Mohamed, Hisanori Kato. Melatonin in bacterial and viral infections with focus on sepsis: a review. Recent Pat Endocr Metab Immune Drug Discov. 2012 Jan;6(1):30-9.
    doi: 10.2174/187221412799015317. PMID: 22264213
  21. Abd El Moneim NA, El Masry H, Sorial MM. A molecular case-control study on the association of melatonin hormone and rs#10830963 single nucleotide polymorphism in its receptor MTNR1B gene with breast cancer. Middle East J cancer. 2015;6:11–20.
  22. Sigurdardottir LG, Markt SC, Rider JR, Haneuse S, Fall K, Schernhammer ES, Tamimi RM, Flynn-Evans E, Batista JL, Launer L, Harris T, Aspelund T, Stampfer MJ, et al. Urinary melatonin levels, sleep disruption, and risk of prostate cancer in elderly men. Eur Urol. 2015;67:191–194.
  23. Zhao M, Wan JY, Zeng K, Tong M, Lee AC, Ding JX, Chen Q. The reduction in circulating melatonin level may contribute to the pathogenesis of ovarian cancer: A retrospective study. J Cancer. 2016;7:831–836.
  24. Wang YM, Jin BZ, Ai F, Duan CH, Lu YZ, Dong TF, Fu QL. The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: A meta-analysis of randomized controlled trials. Cancer Chemother Pharmacol. 2012;69:1213–1220.