子宫肌瘤 | Uterine Fibroids

子宮肌瘤

子宮肌瘤是育齡婦女最常見的疾病,25歲時影響25%的非洲裔美國婦女,到更年期時影響80%的非洲裔美國婦女。2,3儘管很明顯子宮肌瘤是一個健康差异問題4,它們影響到所有種族的女性,每年給美國醫療體系新增數十億美元的成本。在全球範圍內,子宮肌瘤也是育齡婦女最重要的疾病之一。儘管問題的嚴重性,非手術治療和醫療選擇是極其有限的。

治療方案有限的一個原因是,與子宮肌瘤的範圍相比,用於子宮肌瘤研究的資金很少。子宮肌瘤是完全值得研究的努力,因為投資還將通知學科和領域:腫瘤生物學,血管生成,機械訊號,纖維化和遺傳學。考慮一下,子宮肌瘤通常會長出許多釐米大小,但很少會轉移。囙此,對資源的投入不僅對子宮肌瘤的認識有好處,而且對許多病理生理狀態和其他醫學領域也有好處。最近,PCORI發起了一項倡議,以解决這一研究經費的差距。生殖科學的這一問題意義重大,因為它反映了資源投資和研究人員努力解决這一普遍疾病的紅利。(1)

部份人體對照研究:

  • 口服蜂膠組顯著縮小子宮肌瘤和子宮體積(2)
  • 口服蜂膠組無潮熱症狀(2)
  • 口服蜂膠組肌瘤體積:治療前:170.6±10.6 / 治療後:15.8±2.1= -90.6%(2)
  • 口服蜂膠組子宮容積: 治療前: 335±10.3 / 治療後:158±12.5= -52.8%(2)
  • 口服蜂膠可能是治療肌瘤的一線藥物(2)
  • 蜂膠陰道給藥對肌瘤有療效(3)
  • 蜂膠陰道給藥:肌瘤體積:治療前: 120.11.9±12.6 / 治療後:90.7±5.1= -24.4%(3)
  • 蜂膠陰道給藥子宮容積:治療前:411±6.2 / 治療後:185±9.1= -55%(3)
  • 褪黑素可能抑制子宮肌瘤生長(4)
  • 褪黑素對子宮肌瘤細胞增殖有明顯的抑制作用(5)
  • 抑制平滑肌瘤細胞外基質的積聚(5)


Uterine fibroids

Uterine fibroids are the most common disease of reproductive-age women, affecting 25% of African American women at the age of 25 1, and up to 80% African American women by the age of menopause.2,3 Although it is clear that uterine fibroids are a health disparity issue4, they affect women of all races and add billions of dollars in cost each year to the US health care system. Globally as well, uterine fibroids are among the most significant diseases of reproductive-age women. Despite the magnitude of the problem, nonsurgical and medical options for treatment are extremely limited.

One reason for the limited treatment options is that funding for research on uterine fibroids has been sparse in comparison to the scope of the problem. Uterine fibroids are wholly deserving of research effort because investments will also inform the disciplines and fields of: tumor biology, angiogenesis, mechanical signaling, fibrosis, and genetics. Consider for a moment that uterine fibroids frequently grow many centimeters in size but only very rarely will metastasize. Thus, investment of resources will pay dividends not only for the understanding of uterine fibroids but also for many pathophysiologic states and other fields of medicine. Recently, PCORI has launched an initiative to address this disparity of research funding. This issue of Reproductive Sciences is significant because it reflects a dividend of investment of resources and investigator effort to address this prevalent disease.(1)

Part of the human control study:

  • In propolis group, uterine fibroids and uterine volume were significantly reduced (2)
  • No hot flashes were found in propolis group (2)
  • The volume of myoma in propolis group: before treatment: 170.6 ± 10.6 / after treatment: 15.8 ± 2.1 = - 90.6% (2)
  • Uterine volume of propolis group: before treatment: 335 ± 10.3 / after treatment: 158 ± 12.5 = - 52.8% (2)
  • Oral Propolis may be the first-line treatment for myoma (2)
  • Vaginal administration of propolis has curative effect on myoma (3)
  • Propolis vaginal administration: myoma volume: before treatment: 120.11.9 ± 12.6 / after treatment: 90.7 ± 5.1 = - 24.4% (3)
  • Uterine volume of propolis vaginal administration: before treatment: 411 ± 6.2 / after treatment: 185 ± 9.1 = - 55% (3)
  • Melatonin may inhibit the growth of uterine leiomyoma (4)
  • Melatonin can inhibit the proliferation of uterine leiomyoma cells (5)
  • Inhibition of extracellular matrix accumulation in leiomyoma (5)


Refs:

  1. Bee propolis, Luperon depot 3.75mg treatment of uterine fibroid. A randomized, controlled clinical trial.Life Sci J2018;15(11):94-97].ISSN: 1097-8135 (Print) /ISSN: 2372-613X (Online).http://www.lifesciencesite.com. 12.doi:10.7537/marslsj151118.12.
  2. Vaginal Bee Propolis Treatment of Uterine fibromyoma A New Modality.J Am Sci2019; 15(3):8-10]. ISSN 1545-1003 (print); ISSN 2375-7264 (online). http://www.jofamericanscience.org.2. doi:10.7537/marsjas150319.02.
  3. Po-Han Lin, Yen‐Ting Tung, Hsin YUAN Chen, Yi-fen Chiang. Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation. November 2019Journal of Pineal Research 68(2). DOI: 10.1111/jpi.12620
  4. Yen-Ting Tung. Effect of melatonin on growth and abnormal deposition of extracellular matrix component in uterine leiomyoma cells. 6th International Conference and Exhibition on Nutrition. September 14-16, 2016 San Antonio, USA. J Nutr Food Sci
  5. Melatonin Promotes Uterine and Placental Health: Potential Molecular Mechanisms.Luiz Gustavo de Almeida Chuffa, Luiz Antonio Lupi, Maira Smaniotto Cucielo, Henrique Spaulonci Silveira, Russel J. Reiter, Fábio Rodrigues Ferreira Seiva. Int J Mol Sci. 2020 Jan; 21(1): 300. Published online 2019 Dec 31. doi: 10.3390/ijms21010300. PMCID: PMC6982088