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蛋白酶

蛋白酶是指具有水解（分解）蛋白質肽鍵催化功能的一類酶。它們也被稱為蛋白水解酶或蛋白酶。蛋白酶水解各種肽鍵的能力不同。每種蛋白酶都有一種特定的肽鍵。蛋白酶的實例包括：真菌蛋白酶、胃蛋白酶、胰蛋白酶、糜蛋白酶、木瓜蛋白酶、鳳梨蛋白酶和枯草杆菌蛋白酶。蛋白水解酶在消化過程中非常重要，因為它們分解蛋白質食物以釋放人體所需的胺基酸。此外，蛋白水解酶已被用於各種形式的治療很長一段時間。隨著一些臨床研究表明其在腫瘤學、炎症、血液流變學控制和免疫調節方面的益處，其在醫學上的應用越來越受到重視。

混合高濃強白酶對抗新冠研究

絲氨酸蛋白酶 Serrapetase

阿拉伯聯合大公國大學醫學與健康科學學院內科學系

在一項研究中，確定了新冠肺炎無症狀病例的患病率，並描述了輕度新冠肺炎患者的症狀。報告稱，在213名新冠肺炎患者中，19.2%在入院前無症狀。 在剩下的輕度新冠肺炎患者中，咳嗽（40.1%）是最常見的症狀，其次是嗅覺减退（39.5%）和痰（39.5%）。 在嗅覺减退的個體中，90%有伴隨症狀，如視力减退、鼻塞或鼻漏。 痰或生產性咳嗽似乎是無症狀和有症狀患者的重要症狀。 咳嗽是最常見的症狀，其次是嗅覺减退和痰，而發熱（>37.5°C）僅在11.6%的患者中出現。 另一項研究報告，鼻塞（62%）是輕度新冠肺炎患者最常見的症狀。

蛋白水解酶可用於治療醫院感染、病毒感染和耐藥感染，尤其是在兒童和老年人群中，因為其相對安全、耐受性和耐藥性較低，且具有協同效應。 幾種蛋白水解酶以協調一致的管道控制和協調病毒進入宿主細胞、複製和擴散。 囙此，蛋白水解酶在干擾宿主細胞中的病毒機制方面可能很重要，並建議在新冠肺炎中有用。

在安全性和有效性方面，它比傳統的非甾體抗炎藥更安全，

在一項多中心、雙盲、安慰劑對照研究中，沙雷肽酶在解决急性或慢性耳鼻咽喉疾病患者的炎症方面顯示出抗炎、抗水腫和纖溶活性

沙雷肽酶可能在新冠肺炎的肺纖維化中有用

蛋白水解活性被認為是氧化條件下的一種二級抗氧化防禦，以及炎症細胞因數的調節和免疫細胞從淋巴結向炎症和損傷組織的遷移（Tiwari，2017）。 SEPD能够抑制生長因數，尤其是TGF-β，同時抑制氧化應激和促炎細胞因數、趨化因數、粘附分子的表達（Fadl等人，2013年；Gupta等人，2017年；Jaiswal和Mishra，2018年），這似乎表明其在肺纖維化治療中的潜在作用。

使用SEPD是合理的，安全有效，並且沒有副作用，這些副作用通常是使用傳統的黏液溶解劑時產生的，這些副作用可能會導致鎮靜、興奮、胃腸道紊亂、呼吸刺激和便秘，

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC82657...

鳳梨蛋白酶 Bromelain

奧馬哈內布拉斯加州大學醫學中心

我們證明鳳梨蛋白酶（從鳳梨莖中分離並用作膳食補充劑）處理可降低VeroE6細胞中ACE-2和TMPRSS2的表達，並顯著降低S-外結構域的表達。 重要的是，鳳梨蛋白酶處理减少了S-外結構域和VeroE6細胞之間的相互作用。 最重要的是，鳳梨蛋白酶治療顯著降低了VeroE6細胞中SARS-CoV-2的感染。 總之，我們的結果表明鳳梨蛋白酶或富含鳳梨蛋白酶的鳳梨莖可能被用作對抗新冠病毒的抗病毒藥物。

鳳梨蛋白酶抑制ACE-2和跨膜蛋白酶絲氨酸蛋白酶-2的表達

鳳梨蛋白酶切割SARS-CoV-2棘突蛋白

鳳梨蛋白酶抑制S-外結構域結合和SARS-CoV-2感染

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC75230...

蛋白水解酶在新冠病毒感染中的作用及有前景的治療方法

義大利羅馬大學臨床科學和轉化醫學系

三種天然代謝物（如熊果酸、香芹酚和齊墩果酸）通過ADME（即吸收、分佈、代謝和排泄）特性以及Lipinski的五定律，是MPro的潜在抑制劑[135]。

Withanone是一種來自Withania somnifera的活性成分，蜂膠的天然酚咖啡酸苯乙酯成分與SARS-CoV-2 Mpro的底物結合袋的高度保守殘基相互作用，其結合自由能估計與N3蛋白酶抑制劑相當[135]。

通過對SARS-CoV-2 Mpro進行對接和分子動力學類比，從茶樹中篩選出三種生物活性分子（烏龍高倍黃素A、茶黃素D和茶黃素-3-O-沒食子酸酯），並與抗病毒藥物進行比較。 與所有測試化合物相比，烏龍茶（藍茶）衍生的分子烏龍高雙黃烷-A表現出最好的分數和更高數量的氫鍵網絡[136]。https://www.ncbi.nlm.nih.gov/pmc/articles/PMC75010...

科學+家、拜塞高濃蛋白酶/70粒

可能適合多學科復康調理:

骨關節痛^（1）、風濕關節痛^（2,3,4）、運動後肌肉觸痛疼痛^（5）、鼻竇敏^（6）、哮喘^（7）、氣道敏感^（7）、傷口癒合^（8,9）、腸激綜合健康^（10）、腸道健康^（11）、結腸健康^（11）、胸口絞痛^（12）、靜脈健康^（12）、膽固醇斑塊^（13）、血小板聚集^（13) 、軟組織損傷^（14)

食用建議：在需要的時期，空腹食用由2至8粒，每日3次；兩餐中間或飯前1小時前食用。

主要成份：黃梨提取物、植物酶提取物、鳳梨蛋白酶、蛋白酶提取物、真菌酸性蛋白酶、枯草杆菌蛋白酶、過氧化氫酶、水瓜蛋白酶、木瓜膠液提取物、番木瓜酶提取物。

規格型號：70粒/腸溶膠囊

儲存：請存放於陰涼乾爽處，避免陽光照射。

注意：

• 為營養補充品，不能代替藥物。
• 如果您正在使用抗凝血藥物、懷孕或哺乳期女士、嬰幼兒，請不要食用本品。
• 食用首月期間，非腹痛攪肚、拉肚子、放屁、疲倦、全身部份酸痛、嗜睡都是正常的適應現象，通常一個月後都會消失。
• 在手術前後2星期停止食用本品。有出血紊亂或有腸道出血或胃潰瘍的人，不能食用；服用抗凝血藥物不可食用本品。
• 血友病患者或正在服用香豆素、肝素和波立維等處方血液稀釋劑，不要食用本成品。
• 如不瞭解問題原因或問題持續，請儘快諮詢醫生。

潜在副作用：

蛋白水解酶通常被認為是安全的，但也會對某些人產生副作用。你可能會出現腹瀉、噁心和嘔吐等消化問題，尤其是服用高劑量時。雖然補充劑更容易引起副作用，但大量食用富含蛋白水解酶的水果也會導致消化不良。過敏反應也會發生。例如，對鳳梨過敏的人也可能對鳳梨蛋白酶過敏，攝入鳳梨蛋白酶會引起皮疹等不良反應。此外，像鳳梨蛋白酶和木瓜蛋白酶這樣的蛋白水解酶可能會干擾像華法林這樣的血液稀釋藥物。木瓜蛋白酶還可以新增血液中某些抗生素的濃度。囙此，在服用蛋白水解酶前諮詢專家是很重要的。

消化反應：

隨著我們建議的補充劑的選擇，處理體內無謂物質、有害細胞似乎不是一個問題。如果使用了一個準確的份量，它往往會在4到6月內快速發生。但去除那些無謂物質、死細胞是一個緩慢得多的過程，有害組織的體積减小得很慢，當有大量有害細胞迅速死亡時，身體必須處理死了的有害細胞的洪流，可能會導致淋巴結腫大並壓迫神經而出現疼痛新增。

原產地：香港

Protease

Protease refers to a group of enzymes that have the catalytic function to hydrolyze (breakdown) peptide bonds of proteins. They are also called proteolytic enzymes or proteinases. Proteases differ in their ability to hydrolyze various peptide bonds. Each type of protease has a specific kind of peptide bonds it breaks. Examples of proteases include: fungal protease, pepsin, trypsin, chymotrypsin, papain, bromelain, and subtilisin. Proteolytic enzymes are very important in digestion as they breakdown the protein foods to liberate the amino acids needed by the body. Additionally, proteolytic enzymes have been used in various forms of therapy for a long time. Their use in medicine is gaining importance as several clinical studies are indicating their benefits in oncology, inflammation, blood rheology control, and immune regulation.

Multidisciplinary Rehabilitation Which May Be Suitable For:

Consumption

When necessary, take 2 to 8 capsules each time, 3 times daily on empty stomach. To be taken in between meals or 1 hour before food.

Healing Reaction

Healing reaction, if any, will occur in the first month of intake. The reactions are normal and will disappear gradually, and one will feel more relieved thereafter.

• Diarrhea, farting, non abdominal pain.
• Feeling tired or drowsy.

Important Note

1. Do not take this supplement if:
   1. Pregnant or lactating.
   2. Children under 18 years of age.
   3. Taking anticoagulants.
   4. Having bleeding disorder or hemophilia, intestinal bleeding or gastric ulcer.
   5. Enduring hemorrhoid.
2. For serious or complicated health condition, please seek doctor's advice before taking.
3. To stop taking if:
   1. Allergic or adverse reactions occur (other than the normal healing reactions listed above).
   2. Not comfortable with the occurrence of healing reactions.
4. To discontinue taking the supplement 4 to 7 days before menstruation, and to continue upon completion of menses. Menstrual flow more or less remains the same.
5. To discontinue with this supplement 2 weeks before and after any surgery.
6. Don’t use the product if you are a hemophiliac or are on prescription blood thinners like Coumadin, heparin and Plavix. The enzymes cause the drugs to work better so there is the possibility of thinning the blood too much.

Potential Side Effects

Proteolytic enzymes are generally considered to be safe, but they can also have side effects on some people. You may have digestive problems such as diarrhea, nausea and vomiting, especially when taking high doses. Although supplements are more likely to cause side effects, eating a lot of fruits rich in proteolytic enzymes can also lead to indigestion. Allergic reactions can also occur. For example, people who are allergic to pineapple may also be allergic to bromelain, which can cause skin rashes and other adverse reactions. In addition, proteolytic enzymes such as bromelain and papain may interfere with hemodilution drugs such as warfarin. Papain can also increase the concentration of some antibiotics in the blood. Therefore, it is important to consult experts before taking proteolytic enzymes.

Digestive Reaction:

With our recommended choice of supplements, it seems that it is not a problem to deal with unnecessary substances and harmful cells in the body. If an accurate portion is used, it tends to happen quickly within 4 to 6 months. However, it is a much slower process to remove those useless substances and dead cells. The volume of harmful tissue decreases very slowly. When a large number of harmful cells die rapidly, the body must deal with the flood of dead harmful cells, which may lead to lymph node enlargement and nerve compression, resulting in pain.

Major Ingredients: Ananase Extract, Plant Protease Concentrate, Bromelains, Proteinase, Tamase, Recepin, Catarase, Summetrin, Nematolyt Extract, Vegetable Pepsin.

Packaging: 70 capsules per bottle.

Origin: Hong Kong, China

參考研究論文 / Refs:

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3. J M Braun ¹ , B Schneider, H J Beuth. Therapeutic use, efficiency and safety of the proteolytic pineapple enzyme Bromelain-POS in children with acute sinusitis in Germany. In Vivo. Mar-Apr 2005;19(2):417-21. PMID: 15796206
4. Lior Rosenberg ¹ , Yuval Krieger, Eldad Silberstein, Ofer Arnon, Igor A Sinelnikov, Alex Bogdanov-Berezovsky, Adam J Singer. Selectivity of a bromelain based enzymatic debridement agent: a porcine study. Burns. 2012 Nov;38(7):1035-40. doi: 10.1016/j.burns.2012.02.011. Epub 2012 Mar 3. PMID: 22385643
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This product is not registered under the Pharmacy and Poisons Ordinance or the Chinese Medicine Ordinance. Any claim made for it has not been subject to evaluation for such registration. This product is not intended to diagnose, treat or prevent any disease.