骨骼密度強度 | Bone Density & Strength

Store / 骨骼密度強度 | Bone Density & Strength

骨質疏鬆症

骨質疏鬆症的病因包括缺乏體力活動、營養不良、潜在疾病、藥物攝入和不可改變的因素，如年齡、性別和熟悉的易感性。充分預防或治療骨質疏鬆症是個人和公眾健康的一個非常重要的目標，因為骨質疏鬆性骨折是造成老年人慢性疼痛、不活動和殘疾的原因。據估計，在世界範圍內，每三分之一的女性和五分之一的50歲以上的男性會因骨質疏鬆導致骨折。現時，骨質疏鬆症的防治有多種治療方法。非藥理學方法，如日常體育活動、戒烟和减少飲酒，是維持骨骼健康的重要輔助因素。此外，在骨質疏鬆症的治療中，建議補充鈣和維他命D，但尚未證明能顯著降低骨折風險。藥物治療包括雙膦酸鹽、人單克隆抗躰治療和選擇性雌激素受體調節劑等物質。雙膦酸鹽是最廣泛使用的藥物，並被指定為“金標準”抗分解代謝治療骨折預防。(1)


水解膠原蛋白於骨骼強度的作用:

  • 脊柱和股骨頸的BMD顯著增加(1)
  • 新增絕經後婦女的骨密度(1)
  • 骨形成新增，骨降解减少(1)
  • 减少絕經後骨質疏鬆婦女骨遺失(2)
  • 補充膠原蛋白肽也可以預防和治療骨質流失(3)


Osteoporosis

The etiology of osteoporosis includes a lack of physical activity, malnutrition, underlying diseases, drug ingestion and non-modifiable factors, such as ageing, gender, and familiar predisposition. Adequate prevention or therapy of osteoporosis is a very important goal for individual and public health, because osteoporotic bone fractures are responsible for chronic pain, inactivity and invalidity in the elderly. It is estimated that, worldwide, every third women, and one in five men over the age of 50, will sustain an osteoporotic-induced bone fracture [1]. At present, there are a number of therapeutic approaches for the prevention and treatment of osteoporosis. Non-pharmacological approaches, such as daily physical activity, smoking cessation and reduction of alcohol consumption, are very important cofactors in maintaining bone health. In addition, supplementation with calcium and vitamin D is recommended in osteoporosis management, but has not been shown to significantly reduce bone fracture risk. Pharmacological treatment includes substances such as bisphosphonates, human monoclonal antibody therapy and selective estrogen receptor modulators. Bisphosphonates are the most widely-used medication and are designated as the “gold standard” anti-catabolic therapy in fracture prophylaxis.(1)

Effects of collagen hydrolysate on bone strength:

  • BMD of spine and femoral neck increased significantly (1)
  • Bone mineral density in newly increased postmenopausal women (1)
  • Bone formation increased and bone degradation decreased (1)
  • Reducing bone loss in postmenopausal women with osteoporosis (2)
  • Collagen peptide supplementation can also prevent and treat bone loss (3)


Refs:

  1. Daniel König,1,* Steffen Oesser,2 Stephan Scharla,3 Denise Zdzieblik,1 and Albert Gollhofer1. Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women—A Randomized Controlled Study. Journal ListNutrientsv.10(1); 2018 JanPMC5793325. Nutrients. 2018 Jan; 10(1): 97. Published online 2018 Jan 16. doi: 10.3390/nu10010097
    PMID: 29337906
  2. JunLi Liu, YiHu Wang, ShuJun Song, XiJie Wang, YaYa Qin, ShaoYan Si , YanChuan Guo. Combined Oral Administration of Bovine Collagen Peptides with Calcium Citrate Inhibits Bone Loss in Ovariectomized Rats. Published: August 10, 2015. https://doi.org/10.1371/journal.pone.0135019
  3. He Zhang, Ying Dong, Bin Qi, Li Liu, Guangxin Zhou, Xueyuan Bai, Chunhui Yang, Daqing Zhao, Yu Zhao, "Preventive Effects of Collagen Peptide from Deer Sinew on Bone Loss in Ovariectomized Rats", Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 627285, 9 pages, 2014. https://doi.org/10.1155/2014/627285

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