腫瘤細胞在轉移過程中的代謝

轉移形成是大多數癌症患者死亡的主要原因。儘管有廣泛的研究，靶向轉移的種子和定植仍然是一個懸而未決的挑戰。直到最近，人們才注意到轉移癌細胞在轉移級聯過程中的每一步都有選擇性地、動態地適應其代謝。此外，許多轉移瘤顯示出不同的代謝特徵，與腫瘤起源，使生存和生長在新的環境。囙此，階段依賴性代謝特徵可能為預防或减少轉移提供治療視窗，而靶向已建立的轉移中產生的新代謝特徵可能允許其根除。

The metabolism of cancer cells during metastasis

Metastasis formation is the major cause of death in most patients with cancer. Despite extensive research, targeting metastatic seeding and colonization is still an unresolved challenge. Only recently, attention has been drawn to the fact that metastasizing cancer cells selectively and dynamically adapt their metabolism at every step during the metastatic cascade. Moreover, many metastases display different metabolic traits compared with the tumours from which they originate, enabling survival and growth in the new environment. Consequently, the stage-dependent metabolic traits may provide therapeutic windows for preventing or reducing metastasis, and targeting the new metabolic traits arising in established metastases may allow their eradication.